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Laufer Center Seminar - Friday, Feb. 5 - Uri Alon - Shared screen with speaker view
Gabor Balazsi
15:49
Hello Everyone! Please feel free to ask questions here in the chat during the talk.
Gabor Balazsi
22:40
Has anyone induced SCs?
Carlos Simmerling
22:48
why do the mice die anyway if they aren't aging?
Corey_w
23:30
Does senescence spread to nearby cells?
Sarah Levovitz
23:59
What about the senescent cells does the drug target?
Karthik Ledalla
24:31
Do SCs behave similarly across different tissues?
Darya Stepanenko
24:50
Senescent cells are cause of aging or the consequence of aging?
jun wang
25:00
Any molecular characteristics of senescent cells except secretion of cytokines? Or is there a set of moelcules/genes we can detect to tell this is a senescent cell 100% sure?
Kellon
25:41
what are the side effects of removing Senescent cell
Bruce Futcher
29:38
Every 20-year old is young in the same way; every 80-year old is old in her own fashion.
Bruce Futcher
37:46
If senescent cells explain only a part of aging, why does the model fit so well?
Helmut Strey
39:55
Can you make a similar model for cancer?
Corey_w
40:42
Could senescent cells reflect a mechanism to protect the organism from cancer. Similarly, do senescent cells behave differently than normal cells.
Rafal Krzyszton
44:54
There are classes of animals (e.g. moon jellyfish) that don't show signs of aging - Can you comment on that? How does it relate to senescence?
Gabor Balazsi
48:28
How is the germline protected from aging? More garbage trucks?
Rafal Krzyszton
48:37
Thank you!
Steven Skiena
51:54
Ok, so what do I do to kill my senescent cells?
Corey_w
52:11
Might there be a reason that senescent cell removal isn't naturally higher? I.e. might there be an optimal level of senescent cells?
Gabor Balazsi
53:06
One way to act is to remove SnC-s. Another would be to reduce fluctuations. Thoughts about that?
Darya Stepanenko
53:12
What about those 2 mice? Why one looks older?
Helmut Strey
53:58
Fasting is speculated to help reduce aging. Could that give the body time to clear senescent cells?
Kimberly Lu
55:42
Does fasting influence cells to shift to focusing on survival as opposed to proliferation?
Bruce Futcher
56:48
Senescent crlls are big. Angelika Amon’s lab has evidence that large cell size is a cause of senescence. Any comment on the large-cell-size-as-a-cause-of-aging idea?
Kimberly Lu
57:34
Thank you!
Shreyoshi Chakraborti
57:59
What’s your thought about diet and aging?
Jin Wang
58:20
Any relationship between ageing and cell cycle?
Joshua Azukas
01:04:24
have others studied the effect of increasing the activity of the "garbage trucks" vs killing the senescent cells with drugs or increasing the number of number of "garbage trucks" with blood transfusions between young and old mice?
Annie Lin
01:05:39
as you remove the senescent cells, does the progression of diseases slow or is there actual reversal of disease?
Kimberly Lu
01:05:41
What is the best way to confirm the presence of senescent cells in living organisms or cells? Would you suggest using a combination of biomarkers?
Joshua Azukas
01:05:46
thank you!
Karthik Ledalla
01:05:51
Going back to the disease model you presented, why conceptually/mechanistically does the incidence start decreasing at older ages? Seems like it would makes more sense to keep going up
jun wang
01:07:15
I think immunotherapy has a tradeoff consequence. Activation of immune system actually causes aging of immune cells and exhaustion of progenitor cells and lower the potential of cells. Is my understanding correct?
Kimberly Lu
01:07:53
Thank you!
Abhik Tambe
01:10:24
Did I understand correctly that aging treatments work by removing senescent cells? Do they inhibit the secreted inflammatory proteins? Is that analogous to more garbage trucks on the street?
Abhik Tambe
01:13:05
Thank you!
Yiming Wan
01:13:55
Thanks very much! Really informative talk!
Kimberly Lu
01:13:57
Thank you very much Dr. Alon for the brilliant talk! I learned a lot from your seminar today.
Jin Wang
01:13:57
Thank you
Shreyoshi Chakraborti
01:14:03
Thank you very much
Eram Kabir
01:14:09
Thank you!
Chaudhary Harris
01:14:09
A true pleasure. Thank you.
Dalton Sakthivadivel
01:14:12
brilliant talk -- thank you!
Joshua Steier
01:14:16
thank you!
Emily Abplanalp
01:14:28
Thank you!
Joseph Cohen
01:14:32
thank you!
Bruce Futcher
01:14:33
Thanks very much Uri!
Bruce Futcher
01:16:44
G. E. Neurohr et al., Excessive Cell Growth Causes Cytoplasm Dilution And Contributes to Senescence. Cell, (2019).Cell size is a determinant of stem cell potential during aging, Jette Lengefeld, et al BioRxiv