Hello Everyone! Please feel free to ask questions here in the chat during the talk.

Has anyone induced SCs?

why do the mice die anyway if they aren't aging?

Does senescence spread to nearby cells?

What about the senescent cells does the drug target?

Do SCs behave similarly across different tissues?

Senescent cells are cause of aging or the consequence of aging?

Any molecular characteristics of senescent cells except secretion of cytokines? Or is there a set of moelcules/genes we can detect to tell this is a senescent cell 100% sure?

what are the side effects of removing Senescent cell

Every 20-year old is young in the same way; every 80-year old is old in her own fashion.

If senescent cells explain only a part of aging, why does the model fit so well?

Can you make a similar model for cancer?

Could senescent cells reflect a mechanism to protect the organism from cancer. Similarly, do senescent cells behave differently than normal cells.

There are classes of animals (e.g. moon jellyfish) that don't show signs of aging - Can you comment on that? How does it relate to senescence?

How is the germline protected from aging? More garbage trucks?

Thank you!

Ok, so what do I do to kill my senescent cells?

Might there be a reason that senescent cell removal isn't naturally higher? I.e. might there be an optimal level of senescent cells?

One way to act is to remove SnC-s. Another would be to reduce fluctuations. Thoughts about that?

What about those 2 mice? Why one looks older?

Fasting is speculated to help reduce aging. Could that give the body time to clear senescent cells?

Does fasting influence cells to shift to focusing on survival as opposed to proliferation?

Senescent crlls are big. Angelika Amon’s lab has evidence that large cell size is a cause of senescence. Any comment on the large-cell-size-as-a-cause-of-aging idea?

Thank you!

What’s your thought about diet and aging?

Any relationship between ageing and cell cycle?

have others studied the effect of increasing the activity of the "garbage trucks" vs killing the senescent cells with drugs or increasing the number of number of "garbage trucks" with blood transfusions between young and old mice?

as you remove the senescent cells, does the progression of diseases slow or is there actual reversal of disease?

What is the best way to confirm the presence of senescent cells in living organisms or cells? Would you suggest using a combination of biomarkers?

thank you!

Going back to the disease model you presented, why conceptually/mechanistically does the incidence start decreasing at older ages? Seems like it would makes more sense to keep going up

I think immunotherapy has a tradeoff consequence. Activation of immune system actually causes aging of immune cells and exhaustion of progenitor cells and lower the potential of cells. Is my understanding correct?

Thank you!

Did I understand correctly that aging treatments work by removing senescent cells? Do they inhibit the secreted inflammatory proteins? Is that analogous to more garbage trucks on the street?

Thank you!

Thanks very much! Really informative talk!

Thank you very much Dr. Alon for the brilliant talk! I learned a lot from your seminar today.

Thank you

Thank you very much

Thank you!

A true pleasure. Thank you.

brilliant talk -- thank you!

thank you!

Thank you!

thank you!

Thanks very much Uri!

G. E. Neurohr et al., Excessive Cell Growth Causes Cytoplasm Dilution And Contributes to Senescence. Cell, (2019).Cell size is a determinant of stem cell potential during aging, Jette Lengefeld, et al BioRxiv